The Mountain States Genetics Regional Collaborative (MSGRC) is one of seven regional collaboratives covering the nation. The MSGRC covers an 8 state region that includes Arizona, Colorado, Montana, New Mexico, Nevada, Texas, Utah and Wyoming. MSGRC is federally funded through Grant H46MC24095 from the US. Department of Health and Human Services, Health Resources and Services Administration (HRSA), Genetic Services Branch. The Texas Health Institute (THI) administers the MSGRC, which began a new five-year grant cycle on June 1, 2012. The MSGRC ensures that individuals with heritable disorders and their families have access to quality care and appropriate genetic expertise and information in the context of a medical home. The MSGRC facilitates regional collaboration, encourages involvement of diverse populations, and supports innovative mini-projects that inform quality improvement and systems change in the newborn screening and clinical genetics health care delivery systems. These collaborative efforts bring together clinical providers, public health professionals, and affected families to fulfill the MSGRC mission.